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The Most Orally Effective Form Of R-ALA!
The main ingredient in Glucophase XR is K-R-Ala. It is a form of Alpha-Lipoic Acid (ALA), which has been called the "ideal antioxidant". It is one of the most potent, free radical scavengers known to man. It protects cell membranes by boosting and recycling inactive antioxidants into active antioxidants. This activation boosts the free radical fighting action of popular antioxidants like vitamin C, vitamin E, and NAC. Alpha-lipoic acid is aimed at improving insulin response and sensitivity, which also helps you burn fat, build lean muscle, and keep blood sugar levels even. This is very important in low-carb/ketogenic diets. The R form of ALA has been shown to increase ATP production which results in strength gains in human muscle tissue and an increase in energy. It also has been shown to raise serum glutathione levels in blood plasma by over 100%. Glutathione is a super antioxidant that kills toxins such as MTBE and cyandine and helps to reduce inflammation. Raising glutathione levels fights inflammation by reducing the cytokine production that causes abnormal cell death and wasting.(1)
What Are The Problems With ALA/R-ALA?
ALA is made up of two enantiomers, S and R. The S part is of no use to us because it has been found to inhibit ATP production in muscle tissue. The R part gives us all of the beneficial effects, including increasing ATP production, lowering oxidative stress, improving metabolic activity and cellular metabolism. Unfortunately, the R form is extremely sensitive and becomes unstable when there are even the smallest changes in light, air, moisture, and temperature. These changes cause it to decay and polymerize into a sticky, rubbery, or glue like substance which is useless in the human body within hours of ingestion. R-ALA is so unstable that is needs to be shipped in dry ice and stored in a cool and dry place at all times. This instability renders the R-ALA orally inactive. Another problem associated with R-ALA is that it is a waxy material that has a tendency to trap high amounts of residual toxic chemicals and waste from manufacturing, including the carcinogenic solvents dichloromethane, ethylene dichloride, MTBE, acetonitrile, cyclohexane, toluene, methanol and ethyl acetate.
How Did We Solve These Problems?
Glucophase XR uses K-R-ALA. Adding Potassium (K) to the R-ALA keeps it stable even in the most extreme temperatures. Stabilizing it keeps it from decaying and polymerizing into a useless substance. Due to rigorous testing and the refinement of R-ALA processing techniques, Designer Supplements can guarantee that Glucophase XR will be free of toxic solvent residues.
Why Is Glucophase XR So Much Better?
Glucophase XR contains K-R-ALA (the most orally effective form of R-ALA), D-Biotin(Vitamin H), Quercetin and its analogs Q3D and Q4D.
The K-R-ALA makes Glucophase XR a powerful insulin mimetic which can reduce carb related obesity or insulin resistance in muscle cells. It has also been shown to increase activity in dead human beta cells (cells that produce insulin), improve insulin sensitivity and increases fatty acid oxidation (fat loss). Insulin is the most anabolic hormone in the human body, but it has its drawbacks. If your body doesn't have enough insulin it can cause muscle wasting however, an abundance of insulin causes fat gain, especially in problem areas like the lower stomach, love handles, hips and butt.
We have added Quercetin and its analogs Q3D and Q4D which have been shown to increase the body's use of carbohydrates by shuttling them into the muscle tissue and preventing the excess from reaching fat cells.(2)
D-Biotin or Vitamin H has been shown to increase cAMP which in turn causes fatty acid oxidation and an increase in energy. D-Biotin also activates human insulin peptide 3, which plays a major role in the development of new muscle tissue.(3) It also helps to enhance ATP synthesis.(4)
D-Biotin is the most effective and therefore most expensive analog of Biotin. (Ten times more expensive.)
Glucophase XR is the first in a series of new Post Ban Era (PBE) products that Designer Supplements is developing to be used by men and women, not only to burn fat and build lean muscle, but to improve overall health.
REFERENCES
- Human pharmacokinetics of ALA chaper 22 Packer et al.. basel hong kong 1997 pp337-360 dose-proportionality of oral thioctic acid coincidence of assessment via pooled plasma individual data, briethaupt-grogler k niebch g et al.. eur j pharm sci 1999 apr 8 (1) 57-65
- Cermak r landgraf s, wolffram s "quercetin glucosides inhibit glucose uptake into brush boarder membrane vesicles of porcine jejunum," BR J nutr 2004 jun;91(6):849-55
- fu p, layfield et al "Synthesis, conformation, receptor binding and biological activities of monbiotinylated human insulin-like peptide-3," j pept res. 2004 feb;63(2):91-8
- Sone H, Sasaki et al "biotin enhances ATP synthesis in panceatic islets of the rat, resulting in reinforcement of glucose-induced insulin secreation," Biochem Biophys Res commun 2004 feb 2004 13;314(3):824-9
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